Motor Neuron Disease (MND) presents as a gradual and debilitating weakening of the brain and nerves, leading to various motor impairments. Early indicators, such as muscle weakness and speech difficulties, necessitate a sophisticated Ayurvedic intervention. Treatment methodologies encompass Shodana procedures, enema (vasti), swedana karma, and Rasayana medicines. These measures are meticulously tailored to address the intricacies of muscular degeneration and aim to enhance the overall quality of life for individuals grappling with MND.